148 Donor Lung Surfactant Protein D Gene Polymorphisms Are Associated with Bronchiolitis Obliterans Syndrome and Mortality after Lung Transplantation

Conclusions: Sirolimus impairs local healing in the lung and may result in cavitation.The incidence of cavitating lung lesions is double in the sirolimus group suggesting a possible association. The risk of cavitities is higher when trough levels above 12 ng/ml. Concurrent infection is a potential confounder. Sirolimus cavitities may be associated with significant worsening in lung function and prognosis is worse when cavity persists or progress.