Heteroaryl derivatives pyrrolidinyl- and - piperidinyl ketone.

The use of a compound of formula I: ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: m is a number from 0 to 3; n is a number from 0 to 2; Ar is: optionally substituted indolyl; optionally substituted indazolyl; optionally substituted azaindolyl; optionally substituted azaindazolyl; 2,3-dihydro-indolyl optionally substituted; 1,3-dihydro-indol-2-on-yl optionally substituted; optionally substituted benzothiophenyl; benzimidazolyl optionally substituted; optionally substituted benzoxazolyl; optionally substituted benzisoxazolyl; benzothiazolyl optionally substituted; optionally substituted benzisothiazolyl; optionally substituted quinolinyl; 1,2,3,4-tetrahydroquinolinyl optionally substituted; quinolin-2-on-yl optionally substituted; isoquinolinyl optionally substituted; naphthalenyl optionally substituted; optionally substituted pyridinyl or optionally substituted thiophenyl; R 1 is: C1-6 alkyl; C2-6 alkenyl; C2-6 alkynyl; hetero-C 1-6 alkyl; halo-C1-6alkyl; halo-C2-6alkenyl; C3-7cycloalkyl; (C3-7cycloalkyl) -C1-6alkyl; (C1-6alkyl) - (C3-6cycloalkyl) -C1-6alkyl; C1-6 alkoxy; C1-6 alkylsulfonyl; C1-6 alkylsulfanyl; optionally substituted aryl; optionally substituted heteroaryl; heterocyclyl-C1-6alkyl; aryl C1-3 alkyl, the aryl portion is optionally substituted; heteroaryl-C1-3alkyl, whose heteroaryl portion is optionally substituted; aryloxy; aryl-C1-6alkoxy; heteroaryloxy; or heteroaryl-C1-6 alkoxy; 2 R is hydrogen; or C1-6 alkyl; and Ra and Rb each independently are hydrogen; C1-6 alkyl; C1-6 alkoxy; halogen; hydroxy; or oxo; or Ra and Rb together form a C1-2 alkylene; wherein optionally substituted means one to four substituents selected from alkyl, cycloalkyl, alkoxy, halogen, haloalkyl, haloalkoxy, cyano, nitro, heteroalkyl, amino, acylamino, mono-alkylamino, di-alkylamino, hydroxyalkyl, alkoxyalkyl, benzyloxy, cycloalkylalkyl, cycloalkoxy , cycloalkylalkoxy, alkylsulfonyloxy, thiophenyl, fghghgh pyridinyl, morpholinocarbonyl, - (CH2) qS (O) rR; - (CH2) q-NR R; - (CH2) qC (= O) -NR R; - (CH2) qC (= O) -C (= O) -NR R; ghfiifg 10 (CH2) q-SO2-NR R; - (CH2) qN (R) -C (= O) -R; - (CH2) qC (= O) -R; or - (CH2) qN (R) -SO2-R; where q is 0 or 1, r is 0 afgh 1 2, R, R, and R are each independienemente hydrogen or alkyl and each R is independently hydrogen, alkyl, hydroxy or alkoxy for the preparation of a medicamenteo for the treatment of depression, anxiety or both.