Characterization of bone forming cells in posttraumatic myositis ossificans by lectins
1992
Summary Lectins were used to characterize bone forming cells in posttraumatic myositis ossificans. The lectins applied were as follows: Aracbis bypogaea (PNA): specific for β-D-galactose (1,3)N-acetyl-D-galactosamin (Gal-1,3 GaINac), Canavalia ensiformis (Con A): specific for cc-D-glucose (D-Glc) and ct-D-mannose (D-Man) and Wheat germ (WGA): specific for N=acetyl(1,4)D-glucosamlne (Glc-NaQ and neuraminic acid. The development of myositis ossificans was characterized by the appearance ofa WGA binding cell population. The lectin-binding sites appeared as a cluster in the supranuclear cytoplasm, corresponding to the Golgi-complex. However, the FGA lectin-binding sites disappeared in the mature form of myositis ossificans. We assume that these lectin binding cells may be the bone marrow derived precursors of myofibroblast-like cells which are responsible for bone formation within the damaged muscle.
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