Irritant power of the principle chlorinated aliphatic solvents on the skin and ocular mucosa of the rabbit

: A study was carried out in the rabbit in order to compare the cutaneous and ocular mucosa irritant powers of the principal aliphatic chloride solvents and of pure hexachlorobutadiene. Using Draize's method, that of the official technique for the assessment of cosmetic products and the interpretation of Kay and Calandra, a study was made of the effects of a single application or instillation of the common aliphatic chloride solvents. Macroscopic observations were followed by histological examination of the lesions and their course. With the exception of trichloro trifluoro-1,2,3-ethane, these substances are primary irritants but their effects on rabbit skin and ocular mucosa differ.