Seeing Atoms by Single-Particle Cryo-EM.

Nakane et al. and Yip et al., for the first time, demonstrate that, with recent technological advances, atomic-resolution structure determination can be achieved by single-particle cryo-electron microscopy (cryo-EM). This breakthrough opens the door for researchers to apply single-particle cryo-EM to obtain atomic structural information for a wide range of protein complexes.