The mechanisms of the development of tissue hypoxia and the criteria for its assessment in patients with hemorrhagic fever with renal syndrome

Comparison of the parameters that characterize the activity of the sympathoadrenal system (urine adrenalin and noradrenalin) and the severity of hypoxia (lactic acid in blood and urine, pyruvic acid in blood and urine, lactate/pyruvate) in patients suffering from hemorrhagic fever with the renal syndrome (HFRS) showed them to be significantly and directly correlated. The time-course of changes in the study parameters mirrors the gravity of the pathological process. The authors hold that the sympathoadrenal system plays the leading role in the development of different types of tissue hypoxia in HFRS patients.