Rationale of noninvasive method of drug administration at the prelymphatic level

: The paper deals with the mode of local drug administration into the biological tissue at the prelympathic level without damaging the skin, which is based on enhancement of skin permeability by exposing to physical factors, including the use of contrast temperatures in the cyclic process of heating-cooling, followed by exposure to contact low-frequency ultrasound. Experimental and clinical studies of the mode versus routine drug administration have shown it to be promising in physiotherapeutic use.