Pyrazolo [1,5-a] pyrimidine as CB1 receptor antagonists

A compound of the following formula [I-II-i]: ** ** Formula wherein R10 is (i) a phenyl group optionally substituted by one to two group (s) selected (s) between a dehalogeno atom, an alkyl group C1-8, C1-8 one difluoroalkyl group a C1-8 trifluoroalkyl group and a dialkyl (C1-8amino) or (ii) a nitrogen-containing heterocyclic group of 5 to 6 saturated or insaturadoopcionalmente substituted by a group selected from members a C1-8 alkyl group, C1-8 one trifluoroalkyl group and agroup C1-8 alkyloxy, R20 is a phenyl group optionally substituted by one to two group (s) selected (s) between a dehalogeno atom and a cyano group, is R0B (1) a group of formula. -SO2N (R01) (R02), (2) a group of formula: -NHCONHR03; (3) a group deformula: -CON (Re) (Rf), (4) a carboxyl group; or (5) C1-8 hydroxyalkyl group; R01 and R02 are the same or diferentesy each is a hydrogen atom, a C1-8 alkyl group or C1-8 carbamoyl group, R03 is unatomo of hydrogen or C1-8 alkyl; Re and Rf are the same or different and each is a dehidrogeno atom, a C1-8 alkyl group or an amino group di (C1-8 alkyl), E is a group of formula: -C (> = O) - or -SO2-, R5A is hydrogen atom or C1-8 alkyl group, and R6A is (A) C1-8 alkyl optionally substituted by a group a group selected from one to three atom (s) dehalogeno, a hydroxyl group , a cyano group, a carboxyl group and an oxycarbonyl group alquilC1-8; or (B) a group of the following formula: Formula ** ** in the ring Ab is a C3-8 cycloalkyl group, R37 is a hydrogen atom, a cyano group, a C1-8 grupoalquilo, a hydroxyalkyl group C1 -8, C1-8 aminoalkyl group, C1-8 carboxyalkyl group, one grupocarboxilo, and an alkyl C1-8 alkyloxycarbonyl group, a carbamoyl optionally substituted by one to dosgrupo (s) (s) selected from a C1 -8 and a di (C1-8 alkyl) amino-C1-8 alkyl, or a group dela following formula: ** ** formula