Effects of rhTSH-Aided Remnant Tissue Ablation with Low Dose I-131 on Salivary Gland Function in Patients with Thyroid Cancer

1341 Objectives: Salivary gland damage is a common adverse effect of high dose radioiodine therapy for thyroid cancer. So far, less is known about possible salivary gland damages following low dose I-131 ablation (RIA) with rhTSH stimulation. The aim of this study was to investigate whether salivary gland damages is induced by low dose RIA for thyroid cancer. Methods: 59 patients with post-surgical papillary thyroid cancer (M/F 15/34, age:27-75yrs.), who were to undergo first time RIA with 30mCi of I-131, were enrolled. None of the patients had previous history of salivary gland disorders, diabetes, or collagen tissue diseases. TSH stimulation was done by i.m. injection of rhTSH for 2 consecutive days. On the next day of 2nd rhTSH, 30 mCi(1.11GBq) of I-131 was administered on an outpatient setting. Also, blood tests of TSH, FT4, thyroglobulin (Tg), and anti-Tg antibody (TgAb) were done. Patients followed a low iodine diet (