Association between Polymorphisms in the Phosphodiesterase 4D (PDE4D) Gene and the Development of Cerebral Stroke in Patients in the Moscow Population

Two polymorphisms in the PDE4D gene – SNP41 (rs152312) and SNP87 (rs2910829), encoding phosphodiesterase 4D – were studied in patients during the acute period of stroke (n = 577) and a control cohort (n = 270). Significant differences between these cohorts were found in the distributions of genotype and allele frequencies for the SNP41 polymorphism. The AA and AG genotypes of the SNP41 polymorphism were found to associated with an elevated risk of developing stroke in the Moscow population (relative risk = 1.6). No association with this disease was found for the SNP87 polymorphism.