189 Prognosis of infective endocarditis :EIMONA Registry

Despite the major advances in diagnostic technology, improvements in antimicrobial selection, and advances in surgical techniques, infective endocarditis remains a disease with high mortality rate, nearly 20%. Aim To determine predictive factors of mortality of infective endocarditis. Methods EIMONA registry includes 220 patients diagnosed with IE according to the Duke University criteria between 1997 and 2007 (125 Men, mean age 36 ± 17 years). Results In-hospital mortality was 18% (41 patients). Endocarditis patients who died were significantly older (51 ± 9 versus 28 ± 14, p= 0.023), and had more frequently symptoms of heart failure (57.2% vs 26.5%, p Univariate analysis on potential risk factors revealed three significant factors: renal failure, embolic accident and heart failure. These same factors were also independent factors for death in multivariate analysis, with OR= 3.2 (95% CI: 1.1-9.6, p=0.03) for renal failure, OR=2.3 (95% CI: 1.1-5, p=0.03) for embolic accidents and OR=4 (95% CI: 1.6-9.8, p= 0.002) for heart failure. Conclusion Infective endocarditis was a complex disease with poor prognosis; our findings may help to identify higher-risk patients for more aggressive treatment or interventions.