Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Centrioles are ancient cellular organelles that build centrosomes, the major microtubule-organizing centers in animal cells. Duplication of centrioles is tightly controlled to ensure that each dividing cell has precisely two centrosomes. Human cancer cells often have extra centrosomes, which has been hypothesized to confer a proliferative advantage. Wong et al. developed small molecules (centrinones) that allowed them to reversibly “delete” centrioles from cells (see the Perspective by Stearns). Surprisingly, cancer cells continued to divide in the absence of centrosomes, whereas normal cells stopped dividing. Science , this issue p. [1155][1]; see also p. [1091][2] [1]: /lookup/doi/10.1126/science.aaa5111 [2]: /lookup/doi/10.1126/science.aac4860