Interaction of cells of the lymphoid organs in the production of antibodies against the influenza virus. Report 1. Localization of the virus in the cells of the spleen

: A study was made of localization of crude and inactivated influenza virus injected intravenously and intraperitoneally. Macrophages were found to engulf the virus penetrating into the spleen; this was shown by the quantitative and qualitative immunofluorescent method, elcetron microscopy and inoculation to syngenous recipients of homogenates of macrophagal and lymphocytic fractions of splenic cells. No virus was revealed in the lymphocytes.