Effects of transfusion of different ratioes of fresh frozen plasma to concentrated red blood cells on coagulation in patients with hemorrhagic shock

Objective To investigate the effects of transfusion of different ratioes of fresh frozen plasma(FFP) to concentrated red blood cells(CRBC) on coagulation in the patients with hemorrhagic shock. Methods On the basis of the ratio of FFP to CRBC(100ml∶1U) tranfused in the fist 24 hours,65 cases with massive blood transfusion were divided into three groups of L (22 cases,FFP∶CRBC=1∶6.5),M(20 cases,FFP∶CRBC=1∶3) and H(23 cases,FFP∶CRBC=1∶1.1).The coagulation-related indexes were analyzed. Results At 6 hours after transfusion,plasma levels of PT,APTT,TT and Fib were remarkably abnormal in three groups.At 12 hours after transfusion,these 4 indexes of group A were normal or nearly normal and much better than those in group L(P0.01),which were better in group M than those in group L. Conclusion Massive blood transfusion is likely to cause the dysturbance of coagulation,for which the transfusion of FFP and CRBC in a ratio of 1∶1 appears to be reasanable in keeping coagulation normal in patients with hemorrhagic shock.