Role of reactive oxygen species in expulsion of Nippostrongylus brasiliensis from rats

To understand the mechanism for the expulsion of Nipposcrongylus brasiliensisfrom rats, age-dependent variations in the metabolism of reactive oxygen species in the parasite and the host intestines were examined, N. brasiliensis showed an age-dependent increase in its susceptibility to xanthine-xanthine oxidase and c-butyl hydroperoxide generated oxidants as well as to H 2 O 2 . Protection obtained with several scavengers suggested that the worms were damaged by the combined action of oxidants generated by the in micro systems employed