The novel mode of action of anthranilic diamide insecticides : Ryanodine receptor activation

Development of insecticides with unique modes of action is necessary to combat resistance. DuPont Crop Protection has discovered a new class of insecticides which provides exceptional control through action on a novel target, the ryanodine receptor. Studies on native and recombinant insect ryanodine receptors demonstrate that the anthranilic diamides bind to a unique site on this receptor, potently releasing calcium from the sarcoendoplasmic reticulum. As this chemistry exhibits greater than 500-fold differential selectivity toward insect, over mammalian, receptors, anthranilic diamides offer an exciting alternative to existing pest-management strategies.