Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

Ensuring drug loading eciency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to signicantly enhance the eciency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages of the proposed method over the passive loading, especially when the dierence between the dimensions of loaded materials and the pore diameter is small, an increase of up to 20-fold can be observed. The technique described in this study can be used for ecient