Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Abstract Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα  and IL-8 release with IC50 values in µM range without cytotoxic activity.