Synthesis, characterization and anticancer activity of newsulphamoyl isatin derivatives

A new series of Schiff bases of 5-sulphamoyl isatin (V) were synthesized by reacting various substituted aromatic aldehydes with 3-hydrazino-5-sulphamoylisatin (IV). The 3-hydrazino-5-sulphamoylisatin was synthesized by reacting 5-sulphamoylisatin with hydrazine hydrate. All the synthesized compounds were characterized by means of their IR, 1HNMR and Mass spectroscopic data. The designed compounds were screened for anticancer activity against Ehrlich Ascites Carcinoma (EAC) in Swiss Albino mice. Antitumor effect was determined by evaluating tumor volume, viable tumor cells count, non-viable tumor cells count and mean survival time. The standard antitumor drug used was 5-Fluorouracil. The results suggest that the compounds Ve, Vf, Vi and Vj exhibited significant antitumor activity.