Immediate effects of lumacaftor/ivacaftor administration on lung function in patients with severe cystic fibrosis lung disease
2017
Abstract Safety-data for lumacaftor/ivacaftor (LUM/IVA) combination therapy in patients with severe lung disease (percent predicted forced expiratory volume in 1s [ppFEV 1 ] 1 : 34 [31–36]) prescribed LUM/IVA. All patients experienced a decline in ppFEV 1 from baseline at 2-hours (median [IQR] relative change: −19 [−21 to −11]%, p 1
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