Cyclic loading inhibits expression of MMP-3 but not MMP-1 in an in vitro rabbit flexor tendon model.

Background Gene expression analysis is useful for assessing cellular behavior and may improve our understanding of the initial cellular response to mechanical load leading to tendon degeneration. This study assessed gene expression of MMP-1 and MMP-3, genes associated with matrix degradation, in tendons exposed to cyclic loads within physiologic range.