Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position

Abstract A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against Serpulina (Treponema) hyodysenteriae , an important animal health pathogen, are reported and indicate that small lipophilic C 4′ substituents serve as useful sugar surrogates in the hygromycin A class.