A method for the preparation of erlotinib hydrochloride

The present invention discloses a process for the preparation of erlotinib hydrochloride, particularly involving synthesis through Dimroth rearrangement erlotinib construct. The present method is based on 2-amino-4,5-bis (2-methoxyethoxy) benzonitrile, dimethoxymethylene based compound and m-aminophenyl acetylene as starting material, prepared by a one-pot reaction erlotinib hydrochloride. The present invention process is stable, mild reaction conditions, easy to enlarge feeding and post-treatment operation is simple, easy separation of purified, reduced waste generation, and can be applied to large-scale production erlotinib hydrochloride.