A case report of hepatocellular carcinoma and concurrent pancreatic neuroendocrine tumor and renal angiomyolipoma in a patient with tuberous sclerosis

Tuberous sclerosis complex (TSC) is an inherited, neurocutaneous disorder that presents with the formation of hamartomas involving multiple organ systems.  Most commonly affected sites include the kidney, heart, and brain. Pancreatic and hepatic lesions are less commonly reported, and there are currently no definitive screening guidelines for abdominal neoplasms in tuberous sclerosis patients. In this case report, we present a patient with TSC who developed pancreatic neuroendocrine tumor, renal angiomyolipoma, and hepatocellular carcinoma.