1252 Ondansetron (ODS) + metoclopramide (MTP) + dexamethasone (DXM) vs Ondansetron + dexamethasone during CDDP based chemotherapy (CT)

During high dose (>50 mg/m 2 ) CDDP based CT, 51 pts randomized to either regimen A (ODS 40 mg IV d 1–2 & 8 mg PO q 8h d 3–5, MTP 20 mg IV q 4h d 1–2 & 20 mg PO q 4h d 3–5 plus DXM 32 mg IV d 1 or regimen B (as above exempting MTP). Pts randomized to A were given B during the 2nd course & vice versa, followed by alternating A&B thereafter. Vomiting & nausea was evaluated for each 24 h & the first 5d. Results . 147 courses were given 70 of A & 77 of B. Vomiting: With A, CR (no vomiting) was achieved in 62 (88%), 39 (56%), 48 (69%), 60 (86%) & 64 (91%) of 70 courses each 1, 2, 3, 4 & 5 d, respectively vs 55 (71%, P  P P P P P  = NS), 51 (66%, P P P P P