Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis

Helen Su,Gang Chen,Umesh B. Gangadharmath,Luis F. Gomez,Qianwa Liang,Fanrong Mu,Vani P. Mocharla,A. Katrin Szardenings,Joseph C. Walsh,Chunfang Xia,Chul Yu,Hartmuth C. Kolb

Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis

2013

Helen Su
Gang Chen
Umesh B. Gangadharmath
Luis F. Gomez
Qianwa Liang
Fanrong Mu
Vani P. Mocharla
A. Katrin Szardenings
Joseph C. Walsh
Chunfang Xia
Chul Yu
Hartmuth C. Kolb

Purpose We identified and validated [18F]-CP18, a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer for caspase-3 activity in apoptotic cells.

Keywords:

Medicine
Nuclear medicine
Caspase 3
Caspase
Apoptosis
Molecular imaging
substrate recognition
Substrate (chemistry)
pet imaging

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