The effect of topically applied corticosteroids on interleukin 1β levels in patients with atopic dermatitis.
2012
Background Atopic dermatitis (AD) is a chronic recurrent disease of childhood. The therapeutics of AD needs to be more tailored given the new cytokine antibodies available. In this scenario we considered interleukin 1 beta (IL-1β) levels before and after therapy with topical corticosteroids.
Objectives To measure the IL-1β levels before and after treatment in patients with AD after 75% improvement in scoring for atopic dermatitis index.
Methods Forty-five subjects with AD were treated with betamethasone ointment and their IL-1β level was measured prior to and following treatment.
Results The IL-1β levels were raised during disease activity and following improvement they decreased in a statistically significant manner. Also the IL-1β levels corresponded with the severity of disease activity.
Conclusions Newer modalities of therapy in the form of cytokine monoclonal antibodies should be studied in a larger scale in AD.
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