(±)-7-deazaaristeromycin lacking the hydroxymethyl substituent

Abstract As part of a plan to uncover new nucleoside based inhibitors of S -adenosyl- l -homocysteine (AdoHcy) hydrolase that are incapable of undergoing competing nucleotide formation, a derivative of 7-deazaaristeromycin (carbocyclic tubercidin) ( 5 ) has been prepared that lacks the C-5′ hydroxymethyl side-chain. This compound did not exhibit appreciable cytotoxicity or activity against a number of DNA and RNA viruses and was not inhibitory towards AdoHcy hydrolase.