Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.
2003
Abstract The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the d -diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.
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