Derivatives of 5-hydroxy-4-aminomethyl-1-cyclohexyl (or cycloheptyl) -3-alkoksikarbonilindolov, their pharmaceutically acceptable salts having antiviral activity, and a method of producing

2008 
1. Derivatives of 5-hydroxy-4-aminomethyl-1-cyclohexyl (or cycloheptyl) -3-alkoksikarbonilindolov general formula (I)! ! wherein X is hydrogen, chloro, iodo, n = 1 or 2,! R3-C1-C5 alkyl,! Alk is C1-C6 alkyl group! R1, R2 are independently selected from C1-C4-alkyl, preferably methyl, or a group NR1R2 is a group corresponding to the formula! ! and pharmaceutically acceptable salts thereof. ! 2. The compound of claim 1 which is 5-hydroxy-4-dimethylaminomethyl-2-methyl-1-cyclohexyl-3-ethoxycarbonylindol. ! 3. A process for the preparation of 5-hydroxy-4-aminomethyl-1-cyclohexyl (or cycloheptyl) -3-alkoksikarbonilindolov general formula (I) according to claim 1, which consists in the fact that 5-hydroxy-2-alkyl-1-cyclohexyl (or cycloheptyl) -3-alkoksikarbonilindol of formula (III) or (IV):! ! wherein the values ​​of radicals R3, Alk, n defined in Claim 1, is subjected to aminomethylation compound of the general formula: CH2 (N (R1R2) 2) 2! wherein R1, R2 defined in Claim 1! in a Mannich reaction to give the corresponding 5-hydroxy-4-aminomethyl-2-alkyl-1-cyclohexyl (or cycloheptyl) -3-alkoksikarbonilindola formula (1). ! 4. A method according to claim 3, characterized in that a compound of formula (unreceived alkilkarboniluksusnogo reacting the corresponding ester of formula! R3COCH2COOAIk,! Wherein R3 values ​​defined in Claim 1! Or with cyclohexylamine cycloheptylamine in presence of a catalytic amount of acid in a solvent to obtain the corresponding alkyl ether β-cyclohexyl (or cycloheptyl) aminovinilkarbonovoy acid of formula (II)!! value wherein R3, Alk, n defined in claim 1,! which is reacted with benzoquinone. 5. a method according to any one of claims 3 and 4, characterized in that as the ester-used alkilkarboniluksusnogo
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