Perindopril/Hydrochlorothiazide Combination in Hypertensive Patients Unresponsive to Hydrochlorothiazide Alone: A Double-Blind, Multicenter Study.

: This study evaluated the efficacy and tolerability of perindopril erbumine, a long-acting ACE inhibitor, added to continuing hydrochlorothiazide (HCTZ) therapy in hypertensive patients (DBP of 95 to 114 mmHg) whose blood pressure did not normalize (supine DBP 10 mmHg). Incidences of adverse experiences were similar among treatment groups. There were no reports of first-dose hypotension. In patients unresponsive to HCTZ alone, the addition of perindopril at doses of 2--8 mg once daily provided safe and effective blood pressure reduction with no added side-effect liability.