Abstract C044: Dietary inflammatory potential prior to diagnosis and risk of all-cause mortality among African-American women with ovarian carcinoma

Background: Chronic inflammation is known to be associated with ovarian carcinogenesis, yet the impact of inflammatory-related exposures on outcomes has been understudied. Given the poor survival for women diagnosed with ovarian cancer, especially African Americans, we sought to examine whether a modifiable source of chronic inflammation, dietary intake as measured by the dietary inflammatory index (DII®), was associated with all-cause mortality among African-American women with ovarian carcinoma. Methods: Data were available from 490 patients enrolled in a multicenter, population-based case-control study of African-American women with ovarian carcinoma, the African-American Cancer Epidemiology Study. Energy-adjusted DII scores were calculated based on prediagnostic dietary intake of foods alone or foods and supplements, as measured by the 2005 Block Food Frequency Questionnaire. We used Cox proportional hazards regression to estimate multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality among ovarian carcinoma overall and among the most common histotype, high-grade serous carcinoma. Results: A more proinflammatory diet (i.e., greater DII including supplements score) was associated with a greater risk of mortality (HR1-unit change in DII=1.06, 95% CI=1.00-1.13), especially among high-grade serous carcinoma, where a 68% increased risk of mortality was observed for the most proinflammatory DII scores compared to the most anti-inflammatory DII scores (HRQuartile4/Quartile1=1.68, 95% CI= 1.04-2.69, ptrend=0.02). No association was observed for the DII excluding supplements, although trends were similar. Conclusions: A more proinflammatory prediagnostic diet is positively associated with all-cause mortality among African-American women with ovarian carcinoma. Increasing the consumption of anti-inflammatory foods (through diet or supplements) may lead to improvements in survival after a diagnosis of ovarian carcinoma. Citation Format: Lauren C. Peres, James R. Hebert, Bo Qin, Kristin A. Guertin, Elisa V. Bandera, Nitin Shivappa, Tareq F. Camacho, Deanna Chyn, Anthony J. Alberg, Jill Barnholtz-Sloan, Melissa L. Bondy, Michele L. Cote, Ellen Funkhouser, Patricia G. Moorman, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Joellen M. Schildkraut. Dietary inflammatory potential prior to diagnosis and risk of all-cause mortality among African-American women with ovarian carcinoma [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C044.