3-Methyl-2-(phenylsulfonamido)butanoic Acid and Its MetalComplexes: Synthesis, Crystal Structure, Antimicrobial, and Enzyme InhibitionActivity
2021
In this study sulfonamide ligand, 3-methyl-2-(phenylsulfonamido)butanoic acid,
has been synthesized and introduced in complexation with metals Cu, Zn, Fe, Ni,
and Cd. Diorganotin and triorganotin complexes have been also prepared. The
synthesized ligand and its metal complexes have been characterized by FTIR and
mass spectrometry, and single crystal X-ray diffraction. The molecules are
connected with each other via N–H···O–Hbond forming 2D polymeric network in the
crystallographic plane (001) with base vectors [100] and [010].
Intermolecular interactions have been also studied by Hirshfeld surface
analysis. Biological activities of the compounds including radical scavenging,
total antioxidant potential, enzyme inhibition, antifungal, and antibacterial
have been tested. Triorganotin carboxylates demonstrate high activity against
four bacterial strains and one fungi (Aspergillus
niger). Transition metal carboxylates (Ni and Fe) have
demonstrated moderate antioxidant activity. Among Sn carboxylates dialkylstannyl
complex has exhibited some response. In case of enzymes inhibition, Ni
carboxylates have demonstrated the highest activity against butyrylcholine
esterase but moderate activity against acetylcholine esterase.
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