SYNTHESIS AND PROPERTIES OF 1-[(ADAMANTAN-1-YL)METHYL]- 3-PYRAZOLYL UREAS

A series of 1,3-disubstituted ureas containing 1,3,5-trisubstituted pyrazole and (adamantan-1-yl)methyl fragments were synthesized in the reaction of 1-(isocyanatomethyl)adamantane with 3- or 4-aminopyrazoles under mild conditions in 67–92% yields. The inhibitory activity of the obtained compounds with respect to human soluble epoxide hydrolase (sEH) was 16.2–50.2 nmol/l, with solubility in water of 45–85 μmol/l.