Разработка полимерных пленок с гентамицина сульфатом для терапевтической коррекции эрозий (псевдоэрозий) шейки матки

Aim. A science-based selection of pharmaceutical factors, such as type of medium and softener, of vaginal pellicles with gentamicin sulfate for therapeutic correction of cervical erosion has been conducted using mathematical experiment planning.Methods and results. It has been established that both factors make significant influence on intensity of gentamicine sulfate release from vaginal pellicles. Moreover, the influence of base significantly exceeds influence of softener.Conclusion. It has been determined that composition of 0,5% solution of gelatin with addition of 2% glycerine provides optimal gentamicine sulfate releasing from vaginal pellicles.