Effects of BCG-PSN on the T Lympocyte Subsets in Peripheral Blood of Patients with sero-resistance of Syphilis

Objective To study the effect of BCG-PSN on the Patients with Sero- resistance of Syphili and to their immunity mechanisms. Methods Tlymphocyte subsets were measured by flow cytometry in peripheral blood of 30 sero-resistance and 30 healthy subjects. Results Before treatment using BCG-PSN, the proportion of CD3+ CD4+ T cell of peripheral blood from patients with Sero-resistance of Syphili were significantly decreased compared with those from NS (CD3+ group P0.001, CD4+ group P0.01), the proportion of CD8+ T cell percentage was increased (P0.001); After treatment using BCG-PSN, the proportion of CD3+ CD4+ T cell of peripheral blood from patients were significantly increased compared with those from NS (P0.001), the proportion of CD8+ T cell percentage was significantly decreased compared with those from non-treated patients. (P 0.001); the proportion of CD3+ CD4+ T cell and the proportion of CD3+ CD8+ T cell from patients with Sero-resistance of Syphili had no significantly change in statistics (P0.05). Conclusions BCG-PSN can regulate the T lymphocyte subset population and the ratio of CD4+ / CD8+ of peripheral blood from patients with Sero-resistance of Syphili. The Patients with Sero-resistance of Syphili can be treated by BCG-PSN auxiliary field.