Investigations on a flexible prolyl-endopeptidase inhibitor in solution by NMR techniques
1999
4-Phenylbutyrylprolylpyrrolidine, an inhibitor of prolyl-endopeptidase, exists in solution as an equilibrium of trans and cis prolyl rotamers. The equilibrium ratio and the exchange rate of the rotamers were measured in several solvents. The conformational preferences of the flexible molecule were studied by NMR, based on proton–proton vicinal coupling constants, NOESY cross peak intensities and aromatic ring current shifts. Copyright 1999 John Wiley & Sons, Ltd.
Keywords:
- Nuclear magnetic resonance spectroscopy
- Proton NMR
- Aromatic ring current
- Carbon-13 NMR
- Carbon-13 NMR satellite
- Nuclear magnetic resonance
- Nuclear magnetic resonance spectroscopy of nucleic acids
- Transverse relaxation-optimized spectroscopy
- Conformational isomerism
- Chemistry
- Stereochemistry
- Deuterium NMR
- Two-dimensional nuclear magnetic resonance spectroscopy
- Computational chemistry
- Fluorine-19 NMR
- Correction
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