SEXUALHORMONE-BINDING GLOBULINE (SHBG) AND FREE TESTOSTERONE (FTE) IN PATIENTS WITH ULLRICH TURNLR SYNDROME(UTS) RECEIVING OXANDROLONE

Our investigation showed that the concentration of SHBG decreased in healthy girls and boys at increased FIE concentrations. It was therefore the aim of the present study to examine the effects of anabolic steroid oxandrolone in SHBG and FTE concentrations in patients with Turner's syndrome. The normal dose to promote growth in patients wilh UTS is 0,1 mg/kg/BW. Our patients received a very low dose of 1,25 mg oxandrolone/doy. We analysed 21 sera of UTS patients. The determination of SHBG concentrations was performed with the IRMA (Famos diagnostics, Oulunsala, Finnland), the concentration of FTE was determined with the RIA (Immunchem.Corporation, Carson, USA). In 7 untreated UIS patients with the pubic hair stage I and II, there were no differences in the concentrations of SHBG (median 70,3 nmol/l) and FTE (median0,52 pg/ml) in comparison to the values obtained in patients of the comparison group (SHBC median: PI 82,1 nmol/l, PII 70.6 nmol/l; FTE median PI 0,22 pg/ml, PII 0,66 pg/ml). In 14 patients with oxandrolone therapy the SHBG concentrations (SHBG median 10,3 nmol/l) were significantly lower than in patients of the comparison group (p=0,0001). Consequently the increase in FTE concentrations was greater than in FTE concentrations of the comparison group. 6 boys with tall stature received testosterone therapy (500 mg testosterone depot/A weeks) in inhibition of growth. With this treatment the SHBG median decreased to only 20,4 nmol/l, although the FTE median increased to 48 pg/ml.