cortisol and subsequent depression in at-risk adolescents Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning

There is a need to identify biologicalmeasures (biomarkers) for depression to improve the specificityof current psychosocial risk profiles, as an aid in validating earlyinterventions and treatments as well as assessing risk forrecurrence. Few biomarkers have been detected for mentaldisorders because of the complexity of the behavioural phenotypesand an incomplete understanding of the neurobiology ofpsychopathology. The limited success of genetic studies to datewith modest main effects (odds ratios of 1.3 or less)