New crystal form of linezolid and preparation method and application thereof

The invention provides a new crystal form V of an oxazolidinone antibacterial, namely (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide (linezolid). Characteristic absorption peaks appear on the crystal X-ray powder diffraction pattern of the crystal at the following reflection angle 2 theta: 7.40 degrees, 13.45 degrees, 14.64 degrees, 17.92 degrees, 19.80 degrees, 21.07 degrees, 22.10 degrees, 25.42 degrees, 27.65 degrees, 28.35 degrees and 29.65+/-0.2 degrees. The invention also provides a preparation method and application of the material in the new crystal form and a pharmaceutical composite containing the material in the crystal form. The material in the crystal form has the advantages of better stability, simple preparation process and lower preparation cost, and the industrial production of the material in the crystal form can be realized.