Use of sustainable organic transformations in the construction of heterocyclic scaffolds

Abstract The present chapter will focus on the recent advances in the design and development of environmentally sustainable organic transformations involving the use of deep eutectic solvents as green and sustainable solvents and catalysts to synthesize structurally diverse drug-like hybrid molecules with the incorporation of medicinally privileged heterocyclic substructures. The heterocyclic scaffolds with structural diversity and molecular complexity will contribute not only to chemical research but also significantly to medicinal and pharmaceutical chemistry research. It will be an important contribution to drug discovery research in view of synthesis of hybrid molecules using multicomponent reactions. Academically, it will be a significant contribution for the advanced graduates pursuing research in green and sustainable organic transformations. Thus, the present chapter will be a significant contribution in view of its importance in the emerging areas of research relating to: 1. Chemical research—organic syntheses and catalyses. 2. Molecular therapeutics and drug discovery research—to generate high-quality innovative small molecule leads. 3. Pharmaceutical and medicinal chemistry—development of new synthetic methodologies based on multicomponent reactions to synthesize drug-like small molecules with medicinally privileged heterocyclic systems. 4. Green and sustainable chemistry—design and developments of sustainable organic transformations using deep eutectic solvents (DESs) as innovative solvents and catalysts.