Synthesis and characterization of copper-specific tetradendate ligands as potential treatment for Alzheimer's disease

Abstract To regulate copper homeostasis for the therapy of Alzheimer's disease, a series of “tetradendate monoquinoline” (TDMQ) ligands consisting of an 8-aminoquinoline nucleus with a bidentate amine side chain attached at the C2 position of the quinoline moiety, both parts being able to take part in copper chelation, were designed. These TDMQ ligands are potentially able to provide the square planar tetradentate coordination sphere, which is preferred for the extraction of copper(II) from amyloids, with a lower as possible molecular weight, to optimize the passage through different physiological barriers.