Circular Dichroism of an Aromatic Guest Induced by a Chiral Steroid Cyclophane in Aqueous Solution and Synthetic Bilayer Membrane

A steroid cyclophane, having L-lysine residues interposed between a tetraaza[6.1.6.1]paracyclophane skeleton and four cholate moieties, furnished a chiral binding site for a hydrophobic aromatic guest in a synthetic bilayer membrane as well as in aqueous solution, as evidenced by induced circular dichroism.