Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model

Jihui Zhao,Rongrong Cui,Lihao Wang,Yingjia Chen,Zunyun Fu,Xiaoyu Ding,Chen Cui,Tianbiao Yang,Xutong Li,Yuan Xu,Kaixian Chen,Xiaomin Luo,Hualiang Jiang,Mingyue Zheng

Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model

2020

Jihui Zhao
Rongrong Cui
Lihao Wang
Yingjia Chen
Zunyun Fu
Xiaoyu Ding
Chen Cui
Tianbiao Yang
Xutong Li
Yuan Xu
Kaixian Chen
Xiaomin Luo
Hualiang Jiang
Mingyue Zheng

Aldehyde oxidase (AOX) is a drug metabolizing molydbo-flavoenzyme that has gained increasing attention because of contribution to the biotransformation in phase I metabolism of xenobiotics. Unfortu...

Keywords:

Biotransformation
Xenobiotic
Aldehyde oxidase
Drug
Chemistry
Drug metabolism
Molecule
Metabolism
Biochemistry
AOX activity

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