The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

Dan Dan Li,Ting Sun,Xiao Qi Wu,Shu Peng Chen,Rong Deng,Shan Jiang,Gong Kan Feng,Jing Xuan Pan,Xiao Shi Zhang,Yi Xin Zeng,Xiao Feng Zhu

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

2012

Dan Dan Li
Ting Sun
Xiao Qi Wu
Shu Peng Chen
Rong Deng
Shan Jiang
Gong Kan Feng
Jing Xuan Pan
Xiao Shi Zhang
Yi Xin Zeng
Xiao Feng Zhu

Background Topotecan produces DNA damage that induces autophagy in cancer cells. In this study, sensitising topotecan to colon cancer cells with different P53 status via modulation of autophagy was examined.

Keywords:

Cancer cell
Colorectal cancer
DNA damage
Cell signaling
Topotecan
Autophagy
Cancer research
Mutation
Wild type
Molecular biology
Biology

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