OPCAB 後landiolol 投与の血行動態改善および心房細動予防効果

Recently, some clinical studies have suggested that beta-blockers may prevent atrial fibrillation afteropen heart surgery. In this study, we administered a low dose of landiolol （ultra short acting beta1-blocker） by continuous infusion postoperatively to evaluate the effects on prevention of atrial fibrillationand hemodynamic stabilization in off-pump coronary artery bypass grafting （OPCAB）. A total of30 patients were given landiolol and studied as landiolol group （L group）, and 50 patients who hadundergone similar operations before were enrolled as control group （C group）. Heart rate was significantlylower in L group without any deterioration of hemodynamics or myocardial disorder. Occurrenceof atrial fibrillation within the 1st postoperative week in L group was statistically less than that in Cgroup. Continuous infusion of landiolol in low dose has beneficial effects on hemodynamic stabilization,heart rate control, and prevention of atrial fibrillation in post-OPCAB.