Stimulation of endocannabinoid receptors is required for reduction of neuroinflammation and restoration of neurogenesis in the aged brain

the peptides are internalised and bind PSD95, disrupting its interaction with PMCA2B. The peptides protect SHSY-5Y neuronal cell lines against cell death induced by glutamic acid (10mM); however, the peptides are not protective against toxicity induced by aggregated beta-amyloid or camptothecin, suggesting that toxicty of these compounds is mediated by other mechanisms. Conclusions: Cyclic PDZ-binding peptides have potential in disrupting interactions of functional proteins in post-synaptic complexes; hexa-D Arg offers an cost-effective method of internalising peptide ligands without the use of the full penetratin sequence on which it is based. The potential of these peptides against neuronal destruction in diseases such as status elipticus or Alzheimer’s disease warrants further investigation.