Anomia in Pregnancy and Iron Preparations(4)
1977
The therapeutic effects of FeD tablet containing 75 mg of ferrous fumarate (FeF) and 50mg of dioctyl sodium sulfosuccinate (DSS) on anemia in pregnant women and constipation which develops as a complication due to pregnancy itself and as the side effect of FeF treatment for anemia in pregnancy was studied.Hemoglobin, red blood cell, number of days with defecation and frequency of defecation were used as the parameters of this study.114 pregnant women, twelve to thirty-two weeks of gestation, who had more than 5 defecation days in a 2-week preceding control period (0-period) were orally medicated with FeF (Pre-FeF) at daily doses of 300 mg (4 tablets) for two weeks (1st period). Thereafter the cross-over study was conducted. After the administration of Pre-FeF for 2 weeks, the subjects were devided into two groups of FeD (G1, 57 cases) and FeF (G2, 57 cases), and daily doses of four tablets of either Fed or FeF were given for two weeks (2 nd period). Then the drugs were crossed over for another two weeks (3 rd period). The cross-over technique under the double blind method was used.Balanced judgement was made in each case on to which drug had greater clinical effects considering the all parameters observed during the four periods of this study. This judgement was solely made by Dr. Imamura, one of the members of this investigation team. In this balanced judgement, FeD was found to be significantly superior to FeF in 63 out of 114 cases (53.3%) and inferior in 14 cases (12.3%).In both groups, both hemoglobin and red cells increased significantly during the 3 rd period and at the end of total period, but did not show any differences between FeD and FeF in the cross-over analysis.As to bowel movements, days and frequency of defecation were significantly increased by FeD and decreased by FeF.
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