Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-cholesterol Diet

The hypocholesterolemic action of grifolin was investigated in terms of its structure–activity relationship with rats fed on a high-cholesterol diet. The results show that the structure of farnesylorcinol was required for the hypocholesterolemic action, and that the effect of grifolin might be elicited, at least in part, through the augmented excretion of cholesterol into the feces.