Molecules TNFalpha modified DNA molecules encoding such modified TNF-alpha and vaccines comprising those molecules TNFalpha and DNA.

The invention relates to a molecule TNF {the (modified human capable of producing the formation of neutralizing antibodies directed against the molecule TNF {the (human wild-type after administration of these molecules TNF {the (modified in a human host. wherein at least one peptide fragment of the molecule TNF {the (human has been replaced by at least one peptide known to contain immunodominant T cell epitope-containing B cell immunodominant and one or more sidewalls of the regions of the molecule human TNF {to (which includes at least one epitope of the TNF cell {the (B, wherein the substitution introduces a substantial change in the amino acid sequence of front leaf {be (and any of the connecting links and / or any of the strands B ', I or D of the back leaf {be (. the TNF {the (modified human or DNA molecules encoding them may be formulated as vaccines modifying TNF { al (op tionally with pharmaceutically acceptable adjuvants, for the prevention or treatment of chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases, cancer, disseminated sclerosis, diabetes, psoriasis, osteoporosis or asthma. They can analyze body fluids for the presence of TNF {to (by contact with a composition containing TNF {the (modified.